Association of Nonmodifiable Risk Factors With Alzheimer Disease Blood Biomarkers in Community-Dwelling Adults in the ESTHER Study

Hannah Stocker; Léon Beyer; Kira Trares; Joshua Stevenson‐Hoare; Dan Rujescu; Bernd Holleczek; Konrad Beyreuther; Ben Schoettker; Klaus Gerwert; Hermann Brenner

doi:10.1212/wnl.0000000000213500

Abstract

1 min read

This population-based study on dementia biomarkers found that P-tau181 was dependent on age and <i>APOEe4</i>; NfL on age and sex; and GFAP on age, sex, <i>APOEe4</i>, and menopause status. GFAP levels and rate of increase were higher in women, especially in premenopausal participants. Future research should confirm these findings and further explore the role of menopause in dementia pathogenesis among women.

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