Antiviral resistance to diketo acids is associated with the mutations T66I, L74M and S230R in the HIV-1 integrase gene

Myriam Witvrouw; Valery Fikkert; Bénédicte Van Maele; Christophe Pannecouque; Nouri Neamati; Terrence R. Burke; Godwin C. G. Pais; De Clercq Erik; Zeger Debyser

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Multiple Mutations in Human Immunodeficiency Virus-1 Integrase Confer Resistance to the Pyranodipyrimidine V-165

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Antiviral resistance to diketo acids is associated with the mutations T66I, L74M and S230R in the HIV-1 integrase gene

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Novel mutations in HIV-1 integrase associated with resistance to diketo acids

Selection of antiviral resistance against diketo derivatives, authentic inhibitors of HIV-1 integration

Development of Resistance against Diketo Derivatives of Human Immunodeficiency Virus Type 1 by Progressive Accumulation of Integrase Mutations

Inhibition of HIV-1 replication and integrase activity by a series of diketo derivatives

Multiple Mutations in Human Immunodeficiency Virus-1 Integrase Confer Resistance to the Pyranodipyrimidine V-165