Antiviral Activity Spectrum of Nucleoside and Nucleotide Analogues

Abstract Several nucleosidelnucleotide analogues offer great potential for the treatment of viral diseases (i) phosphonylmethoxyalkylpurines and -pyrimidines for adeno-, herpes-, pox-, hepadna- and retroviruses; (ii) neplanocin A analogues for pox-, paramyxo-, arena-, rhabdo- and reoviruses; (iii) acyclic 6–phenylthiouridine derivatives for human immunodeficiency virus type 1.