Antiviral Activity of 3-(3,5-Dimethylbenzyl)Uracil Derivatives Against Hiv-1 and HCMV
Article 2007 en
Authors
TM
Tokumi Maruyama
YD
Yosuke Demizu
SK
Shigetada Kozai
Abstract
1 min read
Antiviral activity of 1,3-disubstituted uracil derivatives was evaluated against HIV-1 and HCMV. It appears that the nitrogen of the 1-cyanomethyl group is important for anti-HIV-1 activity, suggesting interaction with the amino acid residues of HIV-1 reverse transcriptase. 1-Arylmethyl derivatives also exhibited good anti-HIV-1 activity; and that of the 2- and 4-picolyl derivatives was particularly excellent.
Tokumi Maruyama, Shigetada Kozai, Yosuke Demizu, Myriam Witvrouw, Christophe Pannecouque, Jan Balzarini, Robert Snoeck, Graciela Andreï, De Clercq Erik
Tokumi Maruyama, Shigetada Kozai, Tetsuo Yamasaki, Myriam Witvrouw, Christophe Pannecouque, Jan Balzarini, Robert Snoeck, Graciela Andreï, De Clercq Erik
Tokumi Maruyama, Yosuke Demizu, Shigetada Kozai, Myriam Witvrouw, Christophe Pannecouque, Jan Balzarini, Robert Snoeck, Graciela Andreï, De Clercq Erik
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