Antiproliferative and Antiviral Activity of Three Libraries of Adamantane Derivatives

Nikola Basarić; Margareta Sohora; Nikola Cindro; Kata Mlinarić‐Majerski; De Clercq Erik; Jan Balzarini

doi:10.1002/ardp.201300345

Abstract

1 min read

Three libraries of adamantane derivatives were synthesized and evaluated for antiviral and antiproliferative activities against a broad variety of DNA and RNA viruses. Whereas none of the compounds exhibit antiviral activity at subtoxic concentrations, antiproliferative activity was found against murine leukemia cells (L1210), human T-lymphocyte cells (CEM), and cervix carcinoma cells (HeLa) for 4, 8, and 10.

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