Abstract : An intreocular insert based on fibroin was designed and optimized. The insert contains a hollow channel that was preloaded with the anti-VEGF antibody bevacizumab. The device was covalently coated with the antibacterial polymer HMPE1 to protect against biofilm formation and the transmission of harmful bacterial to the interior of the ocular chamber.
Nicholas S. Emonson, Bhagya Dharmasiri, Edward Gordon, Ameya Borkar, Ben Newman, Y. Athulya Wickramasingha, Piers Coia, Timothy Harte, Jazmyn Newton, Benjamin J. Allardyce, Filip Stojcevski, David Kaplan, Luke C. Henderson
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