Antimicrobial activities and enzyme inhibition effects of Nepeta species

Various Nepeta species, widely used among the public, have valuable phytochemical contents and clinical and biological activities. For this reason, our study examined the enzyme inhibition and antibacterial properties of methanol: chloroform (1:1) extracts of six Nepeta species. N. aristata showed a higher inhibitory effect than the standard drug on seven of the eight enzymes studied. N. baytopii had a high inhibition effect on urease and lipase. It was determined that N. italica inhibited other enzymes except for urease, CA, and lipase. In addition, BChE is also the only effective plant. N. nuda subsp. albiflora has a high effect on inhibiting urease, AChE, and lipase. N. stenantha and N. trachonitica also showed inhibition effects on urease, AChE, and tyrosinase. In the disc diffusion method of antibacterial activity, extracts against B. cereus had antibacterial activity. The antimicrobial activity of N. aristata extract was effective against P. aerugonisa and K. pneumoniae. Additionally, when looking at the minimum inhibition concentration method of antibacterial activity, Nepeta extracts were effective against most bacteria. This research determined Nepeta extracts are effective natural products with antioxidant and enzyme inhibition activities.