The optimal management of hypertension in individuals aged 80 years or older with frailty remains uncertain due to multiple gaps in evidence. Complex health issues, polypharmacy, and limited physiological reserve make responding to antihypertensive treatments unpredictable. Patients in this age group may have limited life expectancy, so their quality of life should be prioritized when making treatment decisions. Further research is needed to identify which patients would benefit from more relaxed blood pressure targets and which antihypertensive medications are preferable or should be avoided. A paradigm shift is required in attitudes towards treatment, placing equal emphasis on deprescribing and prescribing when optimizing care. This review discusses the current evidence on managing hypertension in individuals aged 80 years or older with frailty, but further research is essential to address the gaps in knowledge and improve the care of this population.
Laura Kolehmainen, Satu Havulinna, Tiia Ngandu, Timo Strandberg, Esko Levälahti, Jenni Lehtisalo, Riitta Antikaínen, Elina Hietikko, Markku Peltonen, Auli Pölönen, Hilkka Soininen, Jaakko Tuomilehto, Tiina Laatikainen, Rainer Rauramaa, Miia Kivipelto, Jenni Kulmala
Alessandro Croce, Grzegorz Bilo, Martino F. Pengo, Antonella Zambon, Davide Soranna, Alice Riccò, Alice Margherita Ornago, Giuseppe Bellelli, Gianfranco Parati
Teemu Niiranen, Renate B. Schnabel, Aletta E. Schutte, Yitschak Biton, Giuseppe Boriani, Claire Buckley, Alan C. Cameron, Albertino Damasceno, Søren Zöga Diederichsen, Wolfram Doehner, Yutao Guo, Richard Hobbs, Boyoung Joung, Graeme J. Hankey, Professor Gregory Lip, Trudie Lobban, Maja‐Lisa Løchen, Georges H. Mairesse, Amam Mbakwem, Peter A. Noseworthy, George Ntaios, Steven R. Steinhubl, George S. Stergiou,
Franco Muggli, Gianfranco Parati, Isabella Hunjan, Clara Stroppa, Mario G. Bianchetti, Bienvenu Muvunyi, Evariste Ntaganda, Alice Umulisa, Vincent Sinabubaraga, Dragana Radovanović
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