Antidepressants in Acute Bipolar Depression

Article AbstractLetter to the EditorBecause this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.To the Editor: We read with interest the meta-analysis by Sidor and MacQueen on antidepressants in bipolar depression,1 which apparently yielded different conclusions from a previous meta-analysis on the same topic.2 In our opinion, though, the newer meta-analysis is at least as inconclusive as the previous one, and the changes introduced in the selection of the trials has just caused a P < .05 to now be P = .06.