Antagonistic pleiotropy: the example of cardiac insulin-like growth factor signaling, which is essential in youth but detrimental in age

Mahmoud Abdellatif; Frank Madeo; Simon Sedej; Guido Guido Kroemer

doi:10.1080/14728222.2023.2178420

Related publications

Article2022

Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity

Mahmoud Abdellatif, Viktoria Trummer-Herbst, Alexander Martin Heberle, Alina Humnig, Tobias Pendl, Sylvère Durand, Giulia Cerrato, Sebastian J. Hofer, Moydul Islam, Julia Voglhuber, José M. Ramos Pittol, Oliver Kepp, Gerald Höefler, Albrecht Schmidt, Peter P. Rainer, Douglas S. Scherr, Dirk von Lewinski, Egbert Bisping, Julie R. McMullen, Abhinav Diwan, Tobias Eisenberg, Frank Madeo, Kathrin Thedieck, Guido Guido Kroemer, Simon Sedej

Chapter in a book1993

Regulation of Insulin-like Growth Factor-I by Nutrition

J M Ketelslegers, J.P. Thissen, Dominique Maiter, T. Fliesen, T. Mauerhoff, S Triest, Billie M. Moats‐Staats, Michael Maes, Louis E. Underwood

Article2005

Decreased dehydroepiandrosterone sulfate but normal insulin-like growth factor in chronic fatigue syndrome (CFS): relevance for the inflammatory response in CFS.

Michael Maes, Ivana Mihaylova, Marcel De Ruyter

Article1989

Dietary Protein Restriction Decreases Insulin-Like Growth Factor I Independent of Insulin and Liver Growth Hormone Binding*

Dominique Maiter, T. Fliesen, Louis E. Underwood, Michael Maes, G. Gérard, Marsha L. Davenport, Jean‐Marie Ketelslegers

Article2009

Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor β actions in hepatocytes—But without modulating bone morphogenetic protein 7 signaling†

O Gressner, Birgit Lahme, Monika Siluschek, Katharina Rehbein, Ralf Weiskirchen, Axel M. Gressner