Analysis of the Relationship Between Metalloprotease-9 and Tau Protein in Alzheimer’s Disease

Mario Hernándes‐Alejandro; Sarita Montaño; Charles R. Harrington; Claude M. Wischik; Andrés Salas‐Casas; Pedro Cortés‐Reynosa; Eduardo Pérez Salazar; Javier Cázares-Ápatiga; Ricardo Apátiga-Pérez; Miguel Ángel Ontiveros‐Torres; George Perry; Mar Pacheco‐Herrero; José Luna‐Muñoz

doi:10.3233/jad-200146

Abstract

1 min read

These observations provide preliminary evidence of an interaction between these two proteins. Post-translational modifications of tau protein, such as C-terminal truncation or phosphorylation of amino acid residues in the MMP-9 recognition site and conformational changes in the protein, such as folding of the N-terminal sequence over the three-repeat domain, could preclude the interaction between MMP-9 and tau protein during stages of NFT development.

Related publications

Article2008

Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer’s disease

Siddhartha Mondragón‐Rodríguez, Gustavo Basurto‐Islas, Ismael Santa‐María, Raúl Mena, Lester I. Binder, Jesús Ávila, Mark A. Smith, George Perry, Francisco García‐Sierra

Article2007

Conformational changes and cleavage of tau in Pick bodies parallel the early processing of tau found in Alzheimer pathology

Siddhartha Mondragón‐Rodríguez, R. Mena, Lester I. Binder, Mark A. Smith, George Perry, Francisco García‐Sierra

Article2019

Phospho-Tau Protein Expression in the Cell Cycle of SH-SY5Y Neuroblastoma Cells: A Morphological Study

Paola Flores-Rodríguez, Charles R. Harrington, Claude M. Wischik, Vanessa Ibarra-Bracamontes, Natanael Zarco, Araceli Navarrete, Alejandra Martínez-Maldonado, Parménides Guadarrama-Ortíz, Ignacio Villanueva‐Fierro, Miguel Ángel Ontiveros‐Torres, George Perry, Alejandra del C. Alonso, Benjamín Florán, José Segovia, José Luna‐Muñoz

Article2018

The sterol regulatory element‐binding protein 2 is dysregulated by tau alterations in Alzheimer disease

Chunyu Wang, Fanpeng Zhao, Katie Shen, Wenzhang Wang, Sandra L. Siedlak, Hyoung‐gon Lee, Clyde F. Phelix, George Perry, Lu Shen, Beisha Tang, Riqiang Yan, Xiongwei Zhu

Article1996

beta PP and Tau interaction. A possible link between amyloid and neurofibrillary tangles in Alzheimer's disease.

Giorgio Giaccone, Barbara Pedrotti, Antonio Migheli, Laura Verga, Giorgio Racagni, Mark A. Smith, George Perry, Luca De Gioia, Carlo Selvaggini, Mario Salmona, Jorge Ghiso, Blas Frangione, Khalid Islam, Orso Bugiani, Fabrizio Tagliavini