Becker's nevus (BN) manifests as a hyperpigmented, sometimes hypertrichotic plaque/patch over the chest and shoulder, and it is in the category of benign cutaneous hamartomas. BN has elongation and fusion of the rete ridge, keratotic plugging, sebaceous hyperplasia, smooth muscle hyperplasia, and hyperpigmentation of the basal/suprabasal layer histologically. This article highlights all issues involved in pathogenesis and treatment options of BN. According to current research, postzygotic ACTB mutations induce BN and Becker's nevus syndrome (BNS). Although several therapy strategies were utilized to treat the pigmentary and hypertrichotic aspects of BN, no definitive standard treatment was identified to far, and further research is needed to better educate BN care.
Samar Alharbi, Rawdha Hameed Fardan, Mustafa Saeed Almahasnah, Nouf Ali Alsaeed, Hiba Hani Kashif, Nawaf Alghamdi, Amani Awadh Alharthi, Sara Abdullah Al Ghamdi, Abdullah Mohamed Asiri, Dhari Ahmed Alharbi
Dolf Segers, Hector Garcia-Garcia, Caroline Cheng, Rini de Crom, Rob Krams, Jolanda J. Wentzel, Anton F. W. van der Steen, Patrick W. Serruys, Pieter J. M. Leenen, Jon D. Laman
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