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AMD3100/CXCR4 Inhibitor — De Clercq Erik (2015) | RDL Network

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AMD3100/CXCR4 Inhibitor

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AMD3100/CXCR4 Inhibitor

Article 2015 en

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The anti-HIV activity of the CXCR4 inhibitor AMD3100 is independent of the CXCR4/HIV coreceptor level

Katrien Princen, Sigrid Hatse, Kurt Vermeire, Gary Bridger, Renato T. Skerlj, De Clercq Erik, Dominique Schols

AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor

G A Donzella,

Authors

De Clercq Erik
KU Leuven

Abstract

1 min read

status: Published

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Publication Info

DOI: 10.3389/fimmu.2015.00276
Year: 2015
Published: —
Language: en

Article Details

Volume: 6
Link Of The Paper: https://doi.org/10.3389/fimmu.2015.00276

Timeline

Created:June 19, 2026

Dominique Schols,

Steven Lin,

José A. Esté,

Kirsten Nagashima,

Paul J. Maddon,

Graham P. Allaway,

Thomas P. Sakmar,

Geoffrey Henson,

De Clercq Erik,

John P. Moore

Potential Clinical Applications of the CXCR4 Antagonist Bicyclam AMD3100

Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4

Sigrid Hatse, Katrien Princen, Gary Bridger, De Clercq Erik, Dominique Schols

Mutations at the CXCR4 interaction sites for AMD3100 influence anti‐CXCR4 antibody binding and HIV‐1 entry

Sigrid Hatse, Katrien Princen, Kurt Vermeire, Lars‐Ole Gerlach, Mette M. Rosenkilde, Thue W. Schwartz, Gary Bridger, De Clercq Erik, Dominique Schols