Agreement of treatment effects for mortality from routinely collected data and subsequent randomized trials: meta-epidemiological survey — Lars G. Hemkens (2016) | RDL Network
Studies of routinely collected health data could give different answers from subsequent randomized controlled trials on the same clinical questions, and may substantially overestimate treatment effects. Caution is needed to prevent misguided clinical decision making.
Linda Kwakkenbos, Mahrukh Imran, Stephen J. McCall, Kimberly A McCord, Ole Frøbert, Lars G. Hemkens, Merrick Zwarenstein, Clare Relton, Danielle B. Rice, Sinéad Langan, Eric I Benchimol, Lehana Thabane, Marion Campbell, Margaret Sampson, David Erlinge, Helena M. Verkooijen, David Moher, Isabelle Boutron, Philippe Ravaud, Jon Nicholl, Rudolf Uher,
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