Advances in Immunotherapy for Hepatocellular Carcinoma

Immune checkpoint inhibitors (ICIs) aim to induce immune responses against tumors and are less likely to develop drug resistance than molecularly targeted drugs. In addition, they are characterized by a long-lasting antitumor effect. However, since its effectiveness depends on the tumor's immune environment, it is essential to understand the immune environment of hepatocellular carcinoma to select ICI therapeutic indications and develop biomarkers. A network of diverse cellular and humoral factors establishes cancer immunity. By analyzing individual cases and classifying them from the viewpoint of tumor immunity, attempts have been made to select the optimal therapeutic drug for immunotherapy, including ICIs. ICI treatment is discussed from the viewpoints of immune subclass of HCC, Wnt/β-catenin mutation, immunotherapy in NASH-related HCC, the mechanism of HPD onset, and HBV reactivation.

Discussion(0)

No comments yet. Be the first to comment.

Publication Info

DOI: 10.3390/cancers15072070
Year: 2023
Published: —
Language: en

Article Details

Volume: 15
Issue: 7
Link Of The Paper: https://doi.org/10.3390/cancers15072070

Timeline

Created:June 19, 2026

Related publications

Article2023

Role of β-Catenin Activation in the Tumor Immune Microenvironment and Immunotherapy of Hepatocellular Carcinoma

Masahiro Morita, Naoshi Nishida, Tomoko Aoki, Hirokazu Chishina, Masahiro Takita, Hiroshi Ida, Satoru Hagiwara, Yasunori Minami, Kazuomi Ueshima, Masatoshi Kudo

Article2020

Immune Phenotype and Immune Checkpoint Inhibitors for the Treatment of Human Hepatocellular Carcinoma

Naoshi Nishida, Masatoshi Kudo

Dataset

Supplementary Material for: Early Antibiotic Exposure Is Not Detrimental to Therapeutic Effect from Immunotherapy in Hepatocellular Carcinoma

Petros Fessas, Muhammad Naeem, Matthias Pinter, Marron T.U., David Szafron, Lorenz Balcar, Anwaar Saeed, Jun T., Sirish Dharmapuri, Anuhya Gampa, Yulei Wang, Umama Khan, Mahvish Muzaffar, Musharraf Navaid, Lee C, Anushi Bulumulle, Yuvraja T.B, Sonal Paul, Neil Nimkar, Dominik Bettinger, Hannah Hildebrand, Abugabal Y.I., Tiziana Pressiani, Nicola Personeni,

Dataset

Supplementary Material for: Immunological Microenvironment Predicts the Survival of the Patients with Hepatocellular Carcinoma Treated with Anti-PD-1 Antibody

Masahiro Morita, Naoshi Nishida, Kazuko Sakai, Tomoko Aoki, Hirokazu Chishina, Mashiro Takita, Ida H., Shingo Hagiwara, Yasunori Minami, Kazuomi Ueshima, Kazuto Nishio, Yukari Kobayashi, Kazuhiro Kakimi, Masatoshi Kudo

Article2021

Early Antibiotic Exposure Is Not Detrimental to Therapeutic Effect from Immunotherapy in Hepatocellular Carcinoma

Petros Fessas, Muntaha Naeem, Matthias Pinter, Thomas U. Marron, David Szafron, Lorenz Balcar, Anwaar Saeed, Tomi Jun, Sirish Dharmapuri, Anuhya Gampa, Yinghong Wang, Uqba Khan, Mahvish Muzaffar, Musharraf Navaid, Pei‐Chang Lee, Anushi Bulumulle, Bo Yu, Sonal Paul, Neil Nimkar, Dominik Bettinger, Hannah Hildebrand, Yehia I. Abugabal, Tiziana Pressiani, Nicola Personeni,

Naoshi Nishida,

Masatoshi Kudo,

Ahmed O. Kaseb,

Huang Y.-H.,

Ang C,

Anjana Pillai,

Lorenza Rimassa,

Naqash A.R.,

Elad Sharon,

Alessio Cortellini,

Pinato D.J.

Naoshi Nishida,

Masatoshi Kudo,

Ahmed O. Kaseb,

Yi‐Hsiang Huang,

Celina Ang,

Anjana Pillai,

Lorenza Rimassa,

Abdul Rafeh Naqash,

Elad Sharon,

Alessio Cortellini,

David J. Pinato