Adult mouse and human organoids derived from thyroid follicular cells and modeling of Graves’ hyperthyroidism — Jelte van der Vaart (2021) | RDL Network
Adult mouse and human organoids derived from thyroid follicular cells and modeling of Graves’ hyperthyroidism
Article 2021 en
Authors
JV
Jelte van der Vaart
LB
Lynn Bosmans
SS
Stijn F. Sijbesma
Abstract
1 min read
Significance The thyroid is essential for maintaining systemic homeostasis by regulating thyroid hormone concentrations in the bloodstream. This study describes an organoid-based model system to study mouse and human thyroid biology. Moreover, the study explores the potential of human organoids for modeling autoimmune disease, the anti-TSH receptor (TSHR) antibody-driven Graves’ hyperthyroidism.
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