Activities of Alkoxyalkyl Esters of Cidofovir (CDV), Cyclic CDV, and ( <i>S</i> )-9-(3-Hydroxy-2-Phosphonylmethoxypropyl)Adenine against Orthopoxviruses in Cell Monolayers and in Organotypic Cultures — Ilya Lebeau (2006) | RDL Network
Activities of Alkoxyalkyl Esters of Cidofovir (CDV), Cyclic CDV, and ( <i>S</i> )-9-(3-Hydroxy-2-Phosphonylmethoxypropyl)Adenine against Orthopoxviruses in Cell Monolayers and in Organotypic Cultures
Article 2006 en
Authors
IL
Ilya Lebeau
GA
Graciela Andreï
FP
Fabiana Dal Pozzo
Abstract
1 min read
The potencies of several alkoxyalkyl esters of acyclic nucleoside phosphonates against vaccinia virus and cowpox virus were evaluated in cell monolayers and three-dimensional epithelial raft cultures. Prodrugs were at least 20-fold more active than their parent compounds. Octadecycloxyethyl-(S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine emerged as the most potent derivative.
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