Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

Seth L. Masters; Aisling Dunne; Shoba Subramanian; Rebecca L. Hull; Gillian M. Tannahill; Fiona A. Sharp; Christine Becker; Luigi Franchi; Eiji Yoshihara; Zhe Chen; N Mullooly; Lisa A. Mielke; James Harris; Rebecca C. Coll; Kingston H. G. Mills; K. Hun Mok; Philip Newsholme; Gabriel Nuñez; Junji Yodoi; Steven E. Kahn; Ed C. Lavelle; Luke O'neill

doi:10.1038/ni.1935

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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

Abstract

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