Activation of the extracellular signal regulated kinase (ERK) pathway in human melanoma

L. Zhuang; C S Lee; Richard A Scolyer; S. McCarthy; Abraham A. Palmer; Xu Dong Zhang; John F. Thompson; Luc Bron; Peter Hersey

doi:10.1136/jcp.2005.025957

Abstract

1 min read

Expression of activated ERK1/2 in melanocytic lesions appears to be related to malignant potential so that activation of ERK1/2 may be important in melanoma progression. These results provide important histological support for the proposal that inhibition of this signalling pathway may be useful in treatment of melanoma.

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