Activation of porcine endothelium in response to xenogeneic serum causes thrombosis independently of platelet activation

Miriam Galbusera; Simona Buelli; Sara Gastoldi; Daniela Macconi; Stefania Angioletti; Cristian Testa; Giuseppe Remuzzi; Marina Morigi

doi:10.1111/j.1399-3089.2005.00203.x

Abstract

1 min read

Xenogeneic complement induces endothelial cell activation and thrombosis which is independent of platelet activation. Complement deposition elicits a rapid generation of ROS that lead to overexpression of endothelial adhesive molecules instrumental for platelet deposition.

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