Both oxypurinol and uric acid react with the myeloperoxidase-derived oxidant hypochlorous acid at physiological pH, and they can protect the elastase-inhibitory capacity of human α1 -antiprotease against inactivation by hypochlorous acid. Allopurinol does not protect α1-antiprotease, possibly because the redox potential of allopurinol at physiological pH is too positive to permit oxidation by hypochlorous acid.
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