ACLY-matizing Macrophages to Histone Modification during Immunometabolic Reprogramming

Niamh C. Williams; Luke O'neill

doi:10.1016/j.it.2019.12.009

Abstract

1 min read

Metabolic reprogramming in macrophages supports effector functions and differs depending on the activating stimulus. Lauterbach et al . now show that early metabolic alterations in macrophages driven by LPS signaling serve to increase the acetyl-CoA pool via citrate metabolism by the ATP-citrate lyase (ACLY), leading to histone acetylation and regulation of TLR-driven gene expression.

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