Abstract P4-13-01: Prospective association between breast cancer risk and an individual dietary index based on the British Food Standards Agency nutrient profiling system

Abstract Background: The Food Standards Agency Nutrient Profiling System (FSA-NPS) constitutes the basis for the Five-Colour Nutrition Label suggested in France to be put on the front-of-pack of food products. At the individual level, a dietary index (FSA-NPS DI) has been derived and validated and corresponds to a weighted mean of all FSA-NPS scores of foods usually consumed by the individual, reflecting the nutritional quality of his/her diet. Our aim was to investigate the association between the FSA-NPS DI and breast cancer risk in a large cohort. Methods: This prospective study included 46,864 women aged over 35y from the NutriNet-Santé cohort (2009-2015) who completed at least three 24h dietary records during the first 2y of follow-up (median follow-up: 4.0y). 555 incident breast cancers were diagnosed. FSA-NPS DI was computed for each subject using the following nutrient content for 100g of each foods and beverages consumed: energy, total sugar, saturated fatty acid, sodium, fruits and vegetables (%), fibres and proteins. Higher values of the FSA-NPS DI correspond to a lower nutritional quality of the diet. Associations were characterized by multivariate Cox proportional hazards models. Results: The FSA-NPS DI was directly associated with breast cancer risk (HR1-point increment=1.06 (1.02-1.11), P-trend=0.005; HRQ5vs.Q1=1.52 (1.11-2.08), P-trend=0.002). These associations were similar after the exclusion of cases diagnosed during the first year of follow-up. Conclusions: In this prospective study, a higher FSA-NPS individual score was associated with an increased breast cancer risk. These results suggested that unhealthy food choices may be associated with a 52% increase in breast cancer risk (FSA-NPS DI ≥7.7 (Q5) vs. <4.1 (Q1)), supporting the public health relevance of developing front-of-pack nutrition labels based on this score. Citation Format: Deschasaux M, Julia C, Zelek L, Kesse-Guyot E, Gourlet V, Lécuyer L, Méjean C, Ducrot P, Peneau S, Latino-Martel P, Fézeu L, Fassier P, Hercberg S, Touvier M. Prospective association between breast cancer risk and an individual dietary index based on the British Food Standards Agency nutrient profiling system [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P4-13-01.