Abstract P151: Duration and Types of Statin Use and Long-Term Risk of Type 2 Diabetes Among Men and Women with Hypercholesterolemia: Findings From 3 Prospective Cohorts

Introduction: Although effective for cardiovascular disease (CVD) prevention, statin use has been associated with an elevated risk of type 2 diabetes (T2D). However, data on duration of use and types of statins are still limited. Hypothesis: We hypothesized that longer duration of statin use was associated greater risk of T2D and the association varied with different types of statin. Methods: We analyzed participants with self-reported hypercholesterolemia from the Nurses’ Health Study (NHS, 30 480 participants), the Nurses’ Health Study II (NHS II, 21 773 participants) and the Health Professionals Follow-up Study (HPFS, 12 064 participants) who were free of diabetes, CVD and cancer at baseline. Information on statin use was self-reported by participants every 2 years from 2000 for NHS and HPFS, and 1999 for NHS II. Incident cases of T2D were first self-reported on the biennial questionnaires and then confirmed by a validated supplementary questionnaire through 2010 or 2011. Participants also reported the...