Abstract 15979: Endothelial Cell Metabolism is Controlled by the Flow-induced Long Non-coding Rna Lncflow2

Introduction: The majority of the human transcriptome consists of non-coding transcripts which may exert regulatory effects on epigenetic and transcriptional processes. Since laminar flow is an important atheroprotective regulator, we analysed its impact on the expression of long non-coding RNAs (lncRNA) in human endothelial cells (EC) by RNA deep sequencing. Among the significantly up-regulated lncRNAs, we confirmed a 3-fold up-regulation of lncflow2 by laminar flow (p Results: Silencing of lncflow2 by GapmeRs reduced sprout formation of ECs (34.7 % reduction, p