Abstract 12494: Association of Plasma n-3 Polyunsaturated Acids Levels with Metabolic and Inflammatory Biomarkers in Patients With Chronic Heart Failure. Data from the GISSI-HF Trial

Aims: Inverse associations between circulating n-3 polyunsaturated acids (n-3 PUFA) levels and inflammatory biomarkers have been reported in subjects with cardiovascular risk factors or with coronary artery disease. We assessed here their relation to metabolic, inflammatory, and cardiac markers in a large cohort of patients with stable chronic heart failure (HF). Methods: Plasma levels of n-3 PUFA (% of total fatty acids in phospholipids, assayed by gas chromatography) and metabolic (adiponectin), inflammatory (C-reactive protein (hsCRP), pentraxin-3 (PTX3), osteoprotegerin (OPG)), or cardiac biomarkers (natriuretic peptide (NT-proBNP), troponin T (hs-cTnT)) were measured at baseline in 1,203 patients with CHF of any etiology and age enrolled in the GISSI-HF trial. Results: Patients with n-3 PUFA levels in the upper third (>5.4%) had more frequently HF of ischemic etiology, lower SBP, milder symptoms of HF (NYHA class II), less often COPD. Levels of n-3 PUFA were inversely related to adiponectin (Spearman...