Abstract 12225: First-in-man Experience With Intracoronary Infusion of Adipose-Derived Regenerative Cells in the Treatment of Patients with ST-Elevation Myocardial Infarction: The Apollo Trial

Background: Autologous adipose-derived regenerative cells (ADRCs) can be readily obtained from subcutaneous adipose tissue in sufficient amount for therapy. The abundance of adipose tissue in patients and the higher frequency of adult stem cells per unit mass allows for fast isolation of cells in less than two hours. This allows for treatment during the same procedure as the harvest of the adipose tissue and can thus be appended to a primary PCI of an AMI. Methods: APOLLO is a prospective, double-blind, randomized, placebo-controlled first-in-man cell therapy study that enrolled 14 patients to determine the safety and feasibility of ADRCs delivered via the intracoronary route in the treatment of patients with a STEMI. Following standard liposuction and cell isolation, patients were randomly assigned 3:1 to receive intracoronary infusion of 20x106 ADRC or placebo within 24 hrs after the primary PCI. Results: At 6 months, SPECT imaging demonstrated a marked improvement in myocardial perfusion defect and an ...