A recurrent question from a primary care physician: How should I treat my COVID-19 patients at home?

During the present public health emergency caused by COVID-19 spreading rapidly worldwide, the focus is mainly on containing the epidemic to provide relief to hospitals meeting unprecedented demands.Primary care physicians, especially in low-and middle-income countries, are therefore now frequently requesting advice on how to treat their COVID-19 patients at home in the early phase of the disease.Here, we provide recommendations for treating the illness at home, based on the pharmacological rationale and the available clinical evidence of efficacy in COVID-19 patients, including results from published clinical trials, for each recommended class of drugs.Moreover, we have drawn on the experiences of one of us who has used his extensive background in the field of infectious diseases, as well as common sense, to treat COVID-19 patients at home.