A Pragmatic Randomized Controlled Trial of Thiopurine Methyltransferase Genotyping Prior to Azathioprine Treatment: the TARGET Study — William G. Newman (2011) | RDL Network
A Pragmatic Randomized Controlled Trial of Thiopurine Methyltransferase Genotyping Prior to Azathioprine Treatment: the TARGET Study
Article 2011 en
Authors
WN
William G. Newman
KP
Katherine Payne
KT
Karen Tricker
Abstract
1 min read
Our work supports the strong evidence that individuals with TPMT variant homozygosity are at high risk of severe neutropenia, whereas TPMT heterozygotes are not at increased risk of ADRs at standard doses of azathioprine.
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