A Phase I Study of FHD-609, a Heterobifunctional Degrader of Bromodomain-Containing Protein 9, in Patients with Advanced Synovial Sarcoma or SMARCB1-Deficient Tumors — J. Andrew Livingston (2024) | RDL Network
A Phase I Study of FHD-609, a Heterobifunctional Degrader of Bromodomain-Containing Protein 9, in Patients with Advanced Synovial Sarcoma or SMARCB1-Deficient Tumors
FHD-609 showed dose-dependent increases in systemic FHD-609 exposure and pharmacodynamic response profiles. The maximum tolerated doses were identified (40 mg twice weekly/80 mg once weekly) and preliminary clinical activity was observed. Future studies of BRD9 degraders will require strict cardiac monitoring given the QTc prolongation observed in this study.
J. Andrew Livingston, Jean Yves Blay, Jonathan C. Trent, Claudia Valverde, Mark Agulnik, Mrinal M. Gounder, Axel Le Cesne, Meredith McKean, Michael J. Wagner, Silvia Stacchiotti, Samuel Agresta, Alfonso Quintás‐Cardama, Sarah A. Reilly, Kathleen Healy, Denice Hickman, Tina Zhao, Alex Ballesteros‐Perez, Alexis Khalil, Michael P. Collins, Jessica Piel, Kim Horrigan, Ariel Lefkovith, Scott Innis, Alexander J. Lazar, Gregory M. Coté, Andrew J. Wagner
J. Andrew Livingston, Jean Yves Blay, Jonathan C. Trent, Claudia Valverde, Mark Agulnik, Mrinal M. Gounder, Axel Le Cesne, Meredith McKean, Michael J. Wagner, Silvia Stacchiotti, Samuel Agresta, Alfonso Quintás‐Cardama, Sarah A. Reilly, Kathleen Healy, Denice Hickman, Tina Zhao, Alex Ballesteros‐Perez, Alexis Khalil, Michael P. Collins, Jessica Piel,
J. Andrew Livingston, Jean Yves Blay, Jonathan C. Trent, Claudia Valverde, Mark Agulnik, Mrinal M. Gounder, Axel Le Cesne, Meredith McKean, Michael J. Wagner, Silvia Stacchiotti, Samuel Agresta, Alfonso Quintás‐Cardama, Sarah A. Reilly, Kathleen Healy, Denice Hickman, Tina Zhao, Alex Ballesteros‐Perez, Alexis Khalil, Michael P. Collins, Jessica Piel, Kim Horrigan,
J. Andrew Livingston, Jean Yves Blay, Jonathan C. Trent, Claudia Valverde, Mark Agulnik, Mrinal M. Gounder, Axel Le Cesne, Meredith McKean, Michael J. Wagner, Silvia Stacchiotti, Samuel Agresta, Alfonso Quintás‐Cardama, Sarah A. Reilly, Kathleen Healy, Denice Hickman, Tina Zhao, Alex Ballesteros‐Perez, Alexis Khalil, Michael P. Collins, Jessica Piel,
J. Andrew Livingston, Jean Yves Blay, Jonathan C. Trent, Claudia Valverde, Mark Agulnik, Mrinal M. Gounder, Axel Le Cesne, Meredith McKean, Michael J. Wagner, Silvia Stacchiotti, Samuel Agresta, Alfonso Quintás‐Cardama, Sarah A. Reilly, Kathleen Healy, Denice Hickman, Tina Zhao, Alex Ballesteros‐Perez, Alexis Khalil, Michael P. Collins, Jessica Piel, Kim Horrigan,
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