A Nontranscriptional Role for HIF-1α as a Direct Inhibitor of DNA Replication

Maimon E. Hubbi; Kshitiz Gupta; Daniele M. Gilkes; Sergio Rey; Carmen Chak‐Lui Wong; Weibo Luo; Deok‐Ho Kim; Chi V. Dang; Andre Levchenko; Gregg L. Friedman

doi:10.1126/scisignal.2003417

Abstract

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In response to hypoxia, HIF-1α induces cell cycle arrest by inhibiting a helicase complex that unwinds DNA in preparation for replication.

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