We have demonstrated the ability to ventilate, create hypoxic stress, and resuscitate neonatal rats. While resuscitation with 21 or 100% oxygen results in a transient increase in oxidative glutathione levels, the oxygen-resuscitated group alone demonstrated a reduction in reduced glutathione 24 h later. Furthermore, these pups can then be returned to their dams for rearing, allowing ongoing evaluation of long-term effects of hypoxia and various modes of resuscitation.
Weronika Duda, Katarzyna Curzytek, Marta Kubera, Małgorzata Iciek, Danuta Kowalczyk‐Pachel, Anna Bilska‐Wilkosz, Elżbieta Lorenc‐Koci, Monika Leśkiewicz, Agnieszka Basta–Kaim, Bogusława Budziszewska, Magdalena Regulska, Joanna Ślusarczyk, Piotr Gruca, Mariusz Papp, Michael Maes, Władysław Lasoń, Lucyna Antkiewicz‐Michaluk
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