A mechanical basis for chromosome function

Nancy Kleckner; Denise Zickler; Gareth H. Jones; Job Dekker; Ruth Padmore; Jim Henle; John W. Hutchinson

doi:10.1073/pnas.0402724101

A mechanical basis for chromosome function

Proceedings of the National Academy of Sciences 101(34): 12592-12597

Article 2004 English

Abstract

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We propose that chromosome function is governed by internal mechanical forces generated by programmed tendencies for expansion of the DNA/chromatin fiber against constraining features.

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