The authors obtained MR and magnetization transfer (MT) imaging of the cervical cord from 25 patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). They found no conventional MR abnormalities, but a reduced peak height of the MT ratio (MTR) histogram. This suggests a reduced amount of "truly" normal cord tissue in CADASIL. A significant correlation was found between the extent of brain lesions and cord MTR, suggesting wallerian degeneration as the substrate of the cord MTR changes.
Marco Rovaris, Elda Judica, Jaume Sastre‐Garriga, Àlex Rovira, Maria Pia Sormani, Béatrice Benedetti, Tijmen Korteweg, Nicola De Stefano, Zhaleh Khaleeli, Xavier Montalbán, Frederik Barkhof, David H. Miller, Chris H. Polman, Alan J. Thompson, Massimo Filippi
Marco Rovaris, Antonio Gallo, Roberto Riva, Angelo Ghezzi, Marco Bozzali, Béatrice Benedetti, Vittorio Martinelli, Andrea Falini, Giancarlo Comi, Massimo Filippi
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