A Liposomal System Capable of Generating CO2 Bubbles to Induce Transient Cavitation, Lysosomal Rupturing, and Cell Necrosis

Min‐Fan Chung; Ko‐Jie Chen; Hsiang‐Fa Liang; Zi‐Xian Liao; Wei‐Tso Chia; Younan Xia; Hsing‐Wen Sung

doi:10.1002/ange.201205482

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A Liposomal System Capable of Generating CO2 Bubbles to Induce Transient Cavitation, Lysosomal Rupturing, and Cell Necrosis

Article 2012 de

Abstract

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Blasen, die Membranen brechen: Nach Endozytose und intrazellulärer Überführung in Lysosome können Ammoniumbicarbonat enthaltende Liposome thermisch induziert CO2-Blasen freisetzen (siehe Schema), die schnell wachsen und in sich zusammenstürzen. Dieser Prozess, bei dem vorübergehend Hohlräume erzeugt werden, kann die Lysosomenmembran schädigen, was zur Freisetzung lysosomaler Proteasen und somit zur Zellnekrose führt.

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A Liposomal System Capable of Generating CO<sub>2</sub> Bubbles to Induce Transient Cavitation, Lysosomal Rupturing, and Cell Necrosis

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A Liposomal System Capable of Generating CO<sub>2</sub> Bubbles to Induce Transient Cavitation, Lysosomal Rupturing, and Cell Necrosis

Noteworthy performance of La<sub>1−x</sub>Ca<sub>x</sub>MnO<sub>3</sub> perovskites in generating H<sub>2</sub> and CO by the thermochemical splitting of H<sub>2</sub>O and CO<sub>2</sub>

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