A fast responsive, highly selective and light-up fluorescent probe for the two-photon imaging of carboxylesterase in living cells — Jianguo Wang (2018) | RDL Network
A fast responsive, highly selective and light-up fluorescent probe for the two-photon imaging of carboxylesterase in living cells
Article 2018 en
Authors
JW
Jianguo Wang
QC
Qingqing Chen
NT
Na Tian
Abstract
1 min read
A fast responsive and two photon fluorescent probe (HCyNAc) for carboxylesterase (CaE) has been designed based on the D-π-A structure of hemicyanine and naphthalene derivatives. After enzymatic reaction, HCyNAc enabled light-up fluorescence assay of CaE over other biologically-relevant species and enzymes, including ROS. Two-photon imaging of endogenous CaE was confirmed in HeLa cells using HCyNAc under 800 nm NIR excitation.
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