A Doubly Axially Chiral Phosphoric Acid Catalyst for the Asymmetric Tandem Oxyfluorination of Enamides

Takashi Honjo; Robert J. Phipps; Vivek Rauniyar; Dean Toste

doi:10.1002/ange.201205383

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A Doubly Axially Chiral Phosphoric Acid Catalyst for the Asymmetric Tandem Oxyfluorination of Enamides

Article 2012 en

Abstract

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Doppelagent: Die enantioselektive Tandem-Oxyfluorierung von Enamiden mit einem doppelt axial-chiralen Phosphorsäurekatalysator wird beschrieben. Die chirale Phosphorsäure katalysiert sowohl den Fluorierungsschritt (in einem Phasentransferprozess) als auch die Addition an das entstehende Imin (in einer Brønsted-Säure-Katalyse).

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