A Controlled Trial of Artemether or Quinine in Vietnamese Adults with Severe Falciparum Malaria

Tran Tinh Hien; Nicholas Day; Nguyen Hoan Phu; Nguyen Thi Hoang; Tran Thi Hong Chau; Pham Phu Loc; Dinh Xuan Sinh; Ly Van Chuong; Ha Vinh; Deborah Waller; Tim Peto; Sir Nicholas White

doi:10.1056/nejm199607113350202

Abstract

1 min read

Artemisinin (qinghaosu) and its derivatives are rapidly effective antimalarial drugs derived from a Chinese plant. Preliminary studies suggest that these drugs may be more effective than quinine in the treatment of severe malaria. We studied artemether in Vietnam, where Plasmodium falciparum has reduced sensitivity to quinine.

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