A common polymorphism in the human insulin-like growth factor binding protein 3 gene

A common polymorphism generated by an A to C transition at nucleotide 7580 in the third intron of the insulin-like growth factor binding protein 3 gene was found. This polymorphism can be identified by Nde 1 restriction of genomic DNA amplified with a specifically designed restriction enzyme site-generating oligonucleotide primer. The frequency of the A and C alleles was estimated at 0·6 and 0·4 in the Caucasians, 0·63 and 0·37 in Blacks, respectively.