This study aimed to identify and analyze the characteristics of highly cited articles in phosphoinositide 3-kinase (PI3K) research using the Science Citation Index Expanded from 1900 to 2016. Altogether 1,922 highly cited papers in seven document types with cited at least 100 times since publication to the end of 2016 from Web of Science Core Collection were found, and a total of 1,556 highly cited articles were published from 1990 to 2014. The articles were analysed in terms of document type, language of publication, trends in publication, journals, Web of Science categories, and publications of countries, institutions, and authors. The results showed that Journal of Biological Chemistry led 211 journals. The top three categories were biochemistry and molecular biology, cell biology, and oncology. The USA took the lead position among 43 countries with 67% of all the highly cited articles, and Harvard University of the USA with 14% of all highly cited articles was the most productive institution. A comprehensive analysis of keywords revealed that activation, pathway, Akt, and apoptosis were recent foci. In addition, classic articles with more than 1,000 citations since publication to the end of 2016 are also discussed.
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