This study was carried out to evaluate the global scientific production of genome sequencing research to assess the characteristics of the research performances and the research tendencies. Data were obtained from Science Citation Index Expanded database during 1991-2010. Conventional methods including document types, journals, categories, countries and institutions were used to analyze publication output to reveal the global performance. The development of genome sequencing research during last 20 years was described by synthetically analyzing the distribution of words in article title, author keywords, and KeyWords Plus in different periods. The results show that disease and protein related researches were the leading research focuses, and comparative genomics and evolution related research had strong potential in the near future. Key words : Genome sequencing, research trend, scientometrics, science citation index expanded ( SCI-Expanded ), word cluster analysis, keywords.
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