A 12-Week, Double-blind Comparison of Olanzapine vs Haloperidol in the Treatment of Acute Mania

Mauricio Tohen; Joseph F. Goldberg; Ana González‐Pinto; J.-M. Azorin; Eduard Vieta; Marie-Christine Hardy-Bayle; William Lawson; Robin Emsley; Fan Zhang; Robert W. Baker; Richard C. Risser; M. Namjoshi; Angela R. Evans; Alan Breier

doi:10.1001/archpsyc.60.12.1218

Abstract

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These data suggest that olanzapine does not differ from haloperidol in achieving overall remission of bipolar mania. However, haloperidol carries a higher rate of extrapyramidal symptoms, whereas olanzapine is associated with weight gain.

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