5-(Thien-2-yl)-2′-deoxyuridine: A New and Potent Inhibitor of Herpes Simplex Virus Type 1 Replication

Piet Wigerinck; Arthur Van Aerschot; De Clercq Erik; Piet Herdewijn

doi:10.1080/07328319108046537

Abstract

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Abstract 5-(Thien-2-yl)-2′-deoxyuridine, synthesized by coupling of 5-iodo-2′-deoxyuridine with 2-trimethylstannylthiophene in the presence of a Pd catalyst, shows potent anti-HSV-1 activity in vitro.

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