5-Hydroxytryptamine receptors in GtoPdb v.2025.1

Ricardo Andrade; P.P.A. Humphrey; Klaus Peter Latté; Luc Maroteaux; Graeme R. Martin; Derek N. Middlemiss; Ewan J. Mylecharane; John F. Neumaier; Stephen J. Peroutka; John A. Peters; Bryan L. Roth; Pramod R. Saxena; Trevor Sharp; Andrew J. Sleight; Carlos M. Villalón; Daniël Hoyer; Rebecca Hills; Katharine Herrick‐Davis; Nicholas M. Barnes; Gordon S. Baxter; Joël Bockaert; Theresa A. Branchek; Amy Butler; Marlene L. Cohen; Aline Dumuis; Richard M. Eglen; Manfred Göthert; Michael R Hamblin; M. Hamon; Paul Hartig; René Hen; Julie G. Hensler; Frank D. Yocca

doi:10.2218/gtopdb/f1/2025.1

Abstract

1 min read

5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [200] and subsequently revised [182]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. The diversity of metabotropic 5-HT receptors is increased by alternative splicing that produces isoforms of the 5-HT2A (non-functional), 5-HT2C (non-functional), 5-HT4, 5-HT6 (non-functional) and 5-HT7 receptors. Unique amongst the GPCRs, RNA editing produces 5-HT2C receptor isoforms that differ in function, such as efficiency and specificity of coupling to Gq/11 and also pharmacology [40, 499]. Most 5-HT receptors (except 5-ht1e and 5-ht5b) play specific roles mediating functional responses in different tissues (reviewed by [478, 394]).

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