4″-H-TSAO-T, A NOVEL PROTOTYPE IN THE HIV-1 SPECIFIC TSAO FAMILY

Esther Lobatón; Sonsoles Velázquez; Ana San‐Félix; De Clercq Erik; Jan Balzarini; Marı́a-José Camarasa

doi:10.1081/ncn-100002357

Abstract

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The first TSAO derivative that lacks the amino group at the 3'-spiro moiety has been prepared. This molecule retained its HIV-1 specificity (NNRTI characteristic) but did not select for any of the classical NNRTI-specific mutations in the NNRTI binding pocket, including 138-Lys (TSAO resistant strain).

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