1,131 publications from this institution
<p>Supplementary Table 1 - PDF file 57K, Supplementary Table 1. Details of platinum sensitivity and best response to olaparib and post-PARPi chemotherapy of the six patients whose tumor samples were analyzed by massively parallel sequencing. (NE: not evaluable)</p>
Abstract In this research, an attempt has been made to evaluate the structural response of multi‐storey composite modular buildings when subjected to lateral wind loads. Finite element (FE) models were developed in Abaqus for a general 10 storey composite modular building, with and without the consideration of lateral load resisting mechanisms of composite shear walls. Concrete filled steel tubular (CFST) columns and composite shear walls were proposed in place of conventional elements to improve the structural resistance, modularity, and construction timeframe. It was observed that under the effect of wind loads, the forces between the modules are transferred primarily by horizontal axial forces. When the effect of sudden module removal is considered along with the wind, the vertical shear forces in the horizontal inter‐module connection increase and the connection becomes critical in shear. Even though the probability of occurrence of critical wind loads and a sudden module loss is rare, it was concluded that the wind forces do not influence the overall stability of the structure in the event of progressive collapse by sudden module removal if an effective lateral load resisting mechanism has been designed.
Abstract • Androgen receptor (AR) signalling is usually necessary for the development and progression of prostate cancer• Androgen depletion is the mainstay of treatment for advanced prostate cancer but responses can be short-lived• AR-signalling frequently remains intact as prostate cancer evolves from androgen sensitive to castration resistant disease (CRPC)• A number of mechanisms may facilitate AR reactivation, including AR overexpression, AR mutation leading to promiscuous ligand binding or constitutive activation, adrenal and intratumoral androgen synthesis, and activated signal transduction pathways• The AR signalling pathway remains a rational therapeutic target in CRPC.
Targeted deep sequencing is a highly effective technology to identify known and novel single nucleotide variants (SNVs) with many applications in translational medicine, disease monitoring and cancer profiling. However, identification of SNVs using deep sequencing data is a challenging computational problem as different sequencing artifacts limit the analytical sensitivity of SNV detection, especially at low variant allele frequencies (VAFs). To address the problem of relatively high noise levels in amplicon-based deep sequencing data (e.g. with the Ion AmpliSeq technology) in the context of SNV calling, we have developed a new bioinformatics tool called AmpliSolve. AmpliSolve uses a set of normal samples to model position-specific, strand-specific and nucleotide-specific background artifacts (noise), and deploys a Poisson model-based statistical framework for SNV detection. Our tests on both synthetic and real data indicate that AmpliSolve achieves a good trade-off between precision and sensitivity, even at VAF below 5% and as low as 1%. We further validate AmpliSolve by applying it to the detection of SNVs in 96 circulating tumor DNA samples at three clinically relevant genomic positions and compare the results to digital droplet PCR experiments. AmpliSolve is a new tool for in-silico estimation of background noise and for detection of low frequency SNVs in targeted deep sequencing data. Although AmpliSolve has been specifically designed for and tested on amplicon-based libraries sequenced with the Ion Torrent platform it can, in principle, be applied to other sequencing platforms as well. AmpliSolve is freely available at https://github.com/dkleftogi/AmpliSolve .
The Stanford BCNU protocol (carmustine, etoposide and cyclophosphamide) is a high-dose conditioning regimen widely used prior to autologous stem cell transplantation. While acute renal failure requiring renal replacement therapy is a known but rare complication of autologous stem cell transplantation, acute nephrotoxicity following carmustine and etoposide has not yet been reported.We present the first case of carmustine-induced acute kidney injury in the setting of autologous stem cell transplantation and perform a review of the literature. Renal failure was associated with a sharp rise in serum creatinine, oliguria and trace proteinuria. Urgent haemodialysis was required; however, renal failure resolved after 7 days.Although a rare complication, its severity mandates close monitoring of renal function as early recognition and treatment may limit long-term sequelae.
© 2017 Elsevier Ltd <br>The present study uses the isogeometric analysis (IGA) to investigate the post-buckling behavior of functionally graded (FG) microplates subjected to mechanical and thermal loads. The modified a strain gradient theory with three length scale parameters is used to capture the size effect. The Reddy third-order shear deformation plate theory with the von Kámán nonlinearity (i.e., small strains and moderate rotations) is employed to describe the kinematics of the microplates. Material variations in the thickness direction of the plate are described using a rule of mixtures. In addition, material properties are assumed to be either temperature-dependent or temperature-independent. The governing equations are derived using the principle of virtual work, which are then discretized using the IGA approach, whereby a C2-continuity requirement is fulfilled naturally and efficiently. To trace the post-buckling paths, Newton's iterative technique is utilized. Various parametric studies are conducted to examine the influences of material variations, size effects, thickness ratios, and boundary conditions on the post-buckling behavior of microplates.
