Contemporary critics argued that counter-insurgency in Malaya represented more than the defeat of militant communism. Britain's campaign against the Malayan Communist Party (MCP) was seen as resulting from British government collaboration with British capitalists to maintain profits at the expense of the legitimate aspirations of Malayan workers. More recently, it has been argued that the declaration of the emergency in June 1948 was a pre-emptive strike intended to ‘resolve the problem of political control’ and prevent the ‘radical nationalist forces organized around the MCP’ from gaining a nation-wide following. According to this view, government strategy was to ‘manage nationalism’ and ‘control’ decolonization so as to preserve the position of British capital in Malaya. For marxists, the emergency is seen as part of the process of establishing ‘neo-colonialism’. Even for less determinist models, the general complicity between British government and British business in colonial counter-insurgency campaigns is apparently clear. In primary-producing territories like Malaya, the harmony of interests between ‘gentlemanly capitalist’ officials and unofficials (centred on the City of London) ensured that after 1945 ‘coercion tended to be the first resort of policy’. The majority of scholarly output on the emergency has focused on official and guerrilla strategies leaving aside the role of business interests. As a result, the relationship between British business and British government has not been explored in depth. The present article seeks to fill this historiographical gap by reassessing official and commercial interaction in politically disturbed Malaya.
A high throughput assay for the determination of the antimalarial piperaquine in plasma has been developed and validated. The assay utilises 96-wellplate formats throughout the whole procedure, and easily enables a throughput of 192 samples a day using a single LC system. Buffer (pH 2.0; 0.05M) containing internal standard was added to 0.25mL plasma in a 96-wellplate (2mL wells). The samples were extracted on a MPC solid phase extraction deep well 96-wellplate (3M Empore). Piperaquine and internal standard were analysed by liquid chromatography with UV detection on a Chromolith Performance (100mm×4.6mm) column with a mobile phase containing acetonitrile–phosphate buffer (pH 2.5; 0.1M) (8:92, v/v) at a flow rate of 3.0mL/min. The within-day precisions for piperaquine were 3.3 and 2.3% at 40 and 1250ng/mL, respectively. The between-day precisions for piperaquine were 5.8 and 1.3% at 40 and 1250ng/mL, respectively. The total assay precisions using 29 replicates over 5 days were 6.7, 4.5 and 2.7% at 40, 200 and 1250ng/mL, respectively. The lower limit of quantification (LLOQ) and the limit of detection (LOD) were 10 and 5ng/mL, respectively using 0.25mL plasma. Using 1mL of plasma, it was possible to decrease LLOQ and LOD to 2.5 and 1.25ng/mL, respectively.
The objective of antimalarial drug treatment in severe malaria is to save the patient's life. In uncomplicated malaria it is to reduce the parasite biomass to zero, or down to a level where host defences can deal with the remainder. Treatment regimens with rapidly eliminated drugs must generally cover four asexual life-cycles (i.e. > 6 days for Plasmodium falciparum and P. vivax) to eradicate all the parasites in the blood. For slowly eliminated drugs, blood concentrations must exceed the parasites' minimum inhibitory concentration (and preferably the minimum parasiticidal concentration) until all parasites have been eradicated. Resistance means that there is a right shift in the concentration-effect relationship. This may be large and abrupt, as with the point mutations that confer pyrimethamine, sulphonamide or atovaquone resistance, or slow and gradual, as with the processes that determine resistance to chloroquine, quinine or mefloquine. Although treatment failure in malaria usually results from poor compliance, inadequate dosing, pharmacokinetic factors or resistance, some infections will recrudesce when none of these factors operates. How parasites persist despite apparently adequate antimalarial treatment remains unresolved.
