This study evaluates the test-retest reliability and validity of self-report measures of physical activity that can be self-administered in classroom settings to 4th grade students. Four different self-report formats were tested on 66 students. To assess test-retest reliabilities, self-report measures were administered on two occasions, separated by a 3-day interval between Time 1 (Friday) and Time 2 (Monday). One-way model intraclass reliabilities ranged from .51 to .74. Three days of monitoring with the Caltrac accelerometer were used as the validity criterion. Only one of the three-weekly recalls, the Weekly Activity Checklist, was supported by significant validity correlations at both Time 1 (r = .34, p < .01) and Time 2 (r = .26, p < .05). The 1-day recall, Yesterday Activity Checklist, correlated significantly (r = .33, p < .01) with the previous day's Caltrac monitor score. Although two of the physical activity recall formats were found to be superior to two others, these data highlight the limitations of children's self-reports. Two self-report formats were found to have modest levels of reliability and validity with 4th grade children when administered in a classroom setting.
No abstract is provided for this article.
This descriptive study explored the potential for public parks and recreation centers as intervention sites for promoting physical activity among youth. Directors (55% women) of 44 recreation centers in San Diego County completed a survey of their centers' physical activity programming for youths ages 3 to 17 years (response rate = 60%). On an average weekday, 373 (SD = 782) youths participated in physical activity at a center. More boys attended than girls (p <.05). Some centers sponsored after-school programs at elementary (41%) and middle (11%) schools but not at high schools (0%). Primary barriers to providing physical activity programs were inadequate staffing (54%), funding (39%), and facilities (32%). Girls and low-income youth were identified as the most difficult populations to reach. Directors reported considerable interest in collaborating on interventions to improve youth activity programs. Public parks and recreation centers are understudied settings with the potential for substantial involvement in efforts to promote youth physical activity.
The Seven-Day Physical Activity Recall interview is commonly used in epidemiologic research, but the methods of training and certifying interviewers have not been studied or standardized. The purpose of this study was to examine the reliability of the Seven-Day Physical Activity Recall interviews after a structured training program. Twenty-one volunteer interviewers participated in a five-session group training program that targeted standardized interview techniques and scoring procedures. Interviewers scored eight videotaped interviews on two occasions to assess scoring skills. Across all videotapes and interviewers, the test-retest reliability was .99. Two interviewers independently interviewed the same person on the same day, and the reliability of kilocalorie expenditure across interviewers was .86. It was concluded that naive individuals can be taught to reliably conduct and score the Seven-Day Physical Activity Recall interview in a brief training program. Key Words: physical activityassessmentinterviews
Objective To examine psychosocial and environmental correlates of active commuting to university (ACU) and explore its association with overall physical activity among college students. Methods The sample included 518 students (mean 22.4years; 59.7% female) from two universities in Valencia, Spain. Weekly estimations of energy expenditure from ACU and total physical activity were obtained. Socio-economic status, self-efficacy, barriers to active transport, access to car and motorbike, access to public transport, walking and cycling facilities and distance to university were assessed. Data were collected April and May of 2009, using a self-administered survey. A structural equation model was used to analyze associations among variables. Results ACU was inversely correlated with access to private motorized transport (car or motorbike). Perception of physical self-efficacy and walking and cycling facilities were positively associated with ACU, while planning/psychosocial barriers were negatively associated. Multivariate modelling explained 19% of variance in ACU. ACU was not related to total daily physical activity. Conclusions Both psychological and environmental variables were significant correlates of ACU. Present findings provide an empirical basis for interventions to increase active transport among university students.
Tumor necrosis factor alpha (TNF alpha) has multiple biological functions including the prolonged activation of the collagenase and c-jun genes, which are regulated via their AP-1 binding sites. We show that incubating human fibroblasts with TNF alpha induces prolonged activation of JNK, the c-Jun kinase, which phosphorylates the transactivation domain of c-Jun. Furthermore, an immune complex kinase assay specifically demonstrates that TNF alpha stimulates the activity of JNK1, the recently described predominant form of JNK. TNF alpha also produces a small and transient increase in extracellular signal-regulated kinase (ERK) activity and no measured increase in Raf-1 kinase activity. On the other hand, epidermal growth factor causes a prolonged activation of Raf-1 kinase and ERK activity and a smaller, more transient activation of JNK, whereas the phorbol ester phorbol 12-myristate 13-acetate causes a small stimulation of Raf-1 kinase and a pronounced stimulation of ERK activity. The activation of JNK by TNF alpha does not correlate with Raf-1 or ERK activity. The kinetics of Raf-1, ERK, and JNK induction by epidermal growth factor, phorbol 12-myristate 13-acetate, or TNF alpha indicate distinct mechanisms of activation in human fibroblasts.
Chronic inflammation promotes tumor development, progression, and metastatic dissemination and causes treatment resistance. The accumulation of genetic alterations and loss of normal cellular regulatory processes are not only associated with cancer growth and progression but also result in the expression of tumor-specific and tumor-associated antigens that may activate antitumor immunity. This antagonism between inflammation and immunity and the ability of cancer cells to avoid immune detection affect the course of cancer development and treatment outcomes. While inflammation, particularly acute inflammation, supports T-cell priming, activation, and infiltration into infected tissues, chronic inflammation is mostly immunosuppressive. However, the main mechanisms that dictate the outcome of the inflammation-immunity interplay are not well understood. Recent data suggest that inflammation triggers epigenetic alterations in cancer cells and components of the tumor microenvironment. These alterations can affect and modulate numerous aspects of cancer development, including tumor growth, the metabolic state, metastatic spread, immune escape, and immunosuppressive or immunosupportive leukocyte generation. In this review, we discuss the role of inflammation in initiating epigenetic alterations in immune cells, cancer-associated fibroblasts, and cancer cells and suggest how and when epigenetic interventions can be combined with immunotherapies to improve therapeutic outcomes.
The thesis of this article is that multilevel interventions based on ecological models and targeting individuals, social environments, physical environments, and policies must be implemented to achieve population change in physical activity. A model is proposed that identifies potential environmental and policy influences on four domains of active living: recreation, transport, occupation, and household. Multilevel research and interventions require multiple disciplines to combine concepts and methods to create new transdisciplinary approaches. The contributions being made by a broad range of disciplines are summarized. Research to date supports a conclusion that there are multiple levels of influence on physical activity, and the active living domains are associated with different environmental variables. Continued research is needed to provide detailed findings that can inform improved designs of communities, transportation systems, and recreation facilities. Collaborations with policy researchers may improve the likelihood of translating research findings into changes in environments, policies, and practices.
