Publications

Particulate methane monooxygenase (pMMO) is an enzyme that oxidizes methane to methanol with high activity and selectivity. Limited success has been achieved in incorporating biologically relevant ligands for the formation of such active site in a synthetic system. Here, we report the design and synthesis of metal-organic framework (MOF) catalysts inspired by pMMO for selective methane oxidation to methanol. By judicious selection of a framework with appropriate topology and chemical functionality, MOF-808 was used to postsynthetically install ligands bearing imidazole units for subsequent metalation with Cu(I) in the presence of dioxygen. The catalysts show high selectivity for methane oxidation to methanol under isothermal conditions at 150 °C. Combined spectroscopies and density functional theory calculations suggest bis(μ-oxo) dicopper species as probable active site of the catalysts.

ABSTRACT We present extensive photometric and spectroscopic observations of the peculiar Type Ia supernova (SN Ia) 2022vqz. It shares many similarities with the SN 2002es-like SNe Ia, such as low luminosity ($M_{B,\rm max}=-18.11\pm 0.16$ mag) and moderate post-peak decline rate (Δm15,B = 1.33 ± 0.11 mag). The nickel mass synthesized in the explosion is estimated as 0.20 ± 0.04 M⊙ from the bolometric light curve, which is obviously lower than that of normal SNe Ia. SN 2022vqz is also characterized by slowly expanding ejecta, with Si ii velocities persisting around 7000 km s−1 since 16 d before peak brightness, unique among all known SNe Ia. While all of these properties imply a lower energy thermonuclear explosion that should leave a considerable amount of unburnt materials, the absent signature of unburnt carbon in spectra of SN 2022vqz is puzzling. A prominent early peak is clearly detected in the Asteroid Terrestrial-impact Last Alert System c- and o-band light curves and in the Zwicky Transient Facility gr-band data within days after the explosion. Possible mechanisms for the early peak are discussed, including the sub-Chandrasekhar-mass double-detonation model and interaction of SN ejecta with circumstellar material. We find that both models face some difficulties in replicating all aspects of the observed data. As an alternative, we propose a hybrid C–O–Ne white dwarf as the progenitor of SN 2022vqz; it can simultaneously reconcile the tension between low ejecta velocity and the absence of carbon. We further discuss the diversity of SN 2002es-like objects and their origin in the context of different scenarios.

Significant advances in science and engineering often emerge at the intersections of disciplines. Nanoscience and nanotechnology are inherently interdisciplinary, uniting researchers from chemistry, physics, biology, medicine, materials science, and engineering. This convergence has fostered novel ways of thinking and enabled the development of materials, tools, and technologies that have transformed both basic and applied research, as well as how we address critical societal challenges. In this Nano Focus, we pose and explore 33 questions whose answers could profoundly impact fields such as energy, electronics, the environment, optics, and medicine. These questions highlight the need for deeper foundational understanding, improved tools and techniques, and innovative applications─each with significant societal relevance. Together, they represent a global call-to-action for the scientific community.

New constraints on the timing of the Cretaceous-Paleogene mass extinction and the Chicxulub impact, together with a particularly voluminous and apparently brief eruptive pulse toward the end of the “main-stage” eruptions of the Deccan continental flood basalt province suggest that these three events may have occurred within less than about a hundred thousand years of each other. Partial melting induced by the Chicxulub event does not provide an energetically plausible explanation for this coincidence, and both geochronologic and magnetic-polarity data show that Deccan volcanism was under way well before Chicxulub/Cretaceous-Paleogene time. However, historical data document that eruptions from existing volcanic systems can be triggered by earthquakes. Seismic modeling of the ground motion due to the Chicxulub impact suggests that the impact could have generated seismic energy densities of order 0.1–1.0 J/m3 throughout the upper ~200 km of Earth’s mantle, sufficient to trigger volcanic eruptions worldwide based upon comparison with historical examples. Triggering may have been caused by a transient increase in the effective permeability of the existing deep magmatic system beneath the Deccan province, or mantle plume “head.” It is therefore reasonable to hypothesize that the Chicxulub impact might have triggered the enormous Poladpur, Ambenali, and Mahabaleshwar (Wai Subgroup) lava flows, which together may account for >70% of the Deccan Traps main-stage eruptions. This hypothesis is consistent with independent stratigraphic, geochronologic, geochemical, and tectonic constraints, which combine to indicate that at approximately Chicxulub/Cretaceous-Paleogene time, a huge pulse of mantle plume–derived magma passed through the crust with little interaction and erupted to form the most extensive and voluminous lava flows known on Earth. High-precision radioisotopic dating of the main-phase Deccan flood basalt formations may be able either to confirm or reject this hypothesis, which in turn might help to determine whether this singular outburst within the Deccan Traps (and possibly volcanic eruptions worldwide) contributed significantly to the Cretaceous-Paleogene extinction.

The previously determined sequence of the murine T-cell gamma gene and its transcription in cloned T lymphocytes suggests that the polypeptide encoded by this gene is generally present in cytotoxic T cells as a 33-kDa monomer in a disulfide-bonded dimer. The gamma chain is also expected to be phosphorylated because a sequence in its cytoplasmic domain is homologous to an active site for serine phosphorylation in the regulatory subunit of cAMP-dependent protein kinase. We describe here a cytotoxic-T-cell-associated phosphorylated protein, many of whose properties suggest that it may be the product of the T-cell gamma gene. Its phosphorylation is greatly enhanced by interleukin 2 stimulation.