Publications

<div>Abstract<p>Natural killer (NK) cells can recognize and kill tumor cells lacking “self” markers, such as class I MHC, but the basis for this recognition is not completely understood. NKR-P1 receptors are members of the C-type lectin-related NK receptor superfamily that are conserved from rodents to humans. Identification of Clr ligands for the NKR-P1 receptors has facilitated functional analysis of MHC-independent target cell recognition by NK cells. One receptor-ligand pair, NKR-P1B:Clr-b, can mediate “missing-self” recognition of tumor and infected cells, but the role of this axis in sensing stressed cells remains unknown. Here, we show that Clr-b is rapidly downregulated in cells undergoing genotoxic and cellular stress at the level of both RNA and surface protein. Stress-mediated loss of Clr-b on leukemia cells enhanced cytotoxicity mediated by NKR-P1B<sup>+</sup> NK cells. Notably, Clr-b downregulation was coordinated functionally with stress-mediated upregulation of NKG2D ligands (but not class I MHC). Our findings highlight a unique role for the MHC-independent NKR-P1B:Clr-b missing-self axis in recognition of stressed cells, and provide evidence of two independent levels of Clr-b regulation in stressed cells. Cancer Res; 70(18); 7102–13. ©2010 AACR.</p></div>

By directly altering microscopic interactions, pressure provides a powerful tuning knob for the exploration of condensed phases and geophysical phenomena. The megabar regime represents an exciting frontier, where recent discoveries include novel high-temperature superconductors, as well as structural and valence phase transitions. However, at such high pressures, many conventional measurement techniques fail. Here, we demonstrate the ability to perform local magnetometry inside of a diamond anvil cell with sub-micron spatial resolution at megabar pressures. Our approach utilizes a shallow layer of Nitrogen-Vacancy (NV) color centers implanted directly within the anvil; crucially, we choose a crystal cut compatible with the intrinsic symmetries of the NV center to enable functionality at megabar pressures. We apply our technique to characterize a recently discovered hydride superconductor, CeH$_9$. By performing simultaneous magnetometry and electrical transport measurements, we observe the dual signatures of superconductivity: local diamagnetism characteristic of the Meissner effect and a sharp drop of the resistance to near zero. By locally mapping the Meissner effect and flux trapping, we directly image the geometry of superconducting regions, revealing significant inhomogeneities at the micron scale. Our work brings quantum sensing to the megabar frontier and enables the closed loop optimization of superhydride materials synthesis.

A comparison of three samples of poly(3-hexylthiophene) having regioregularities of 86, 90, and 96% is used to elucidate the effect of regioregularity on polymer-fullerene-composite solar cell performance. It is observed that polymer samples with lower regioregularity are capable of generating fullerene composites that exhibit superior thermal stability. The enhanced thermal stability of the composites is attributed to a lower driving force for polymer crystallization in the less regioregular polymer samples, which is supported with two-dimensional grazing incidence X-ray scattering and differential scanning calorimetry measurements. Furthermore, it is demonstrated that all three polymer samples are capable of generating solar cells with equivalent peak efficiencies of approximately 4% in blends with [6,6]-phenyl-C61-butyric acid methyl ester. While it may be non-intuitive that polymers with lower regioregularity can exhibit higher efficiencies, it is observed that the charge-carrier mobility of the three polymers is on the same order of magnitude (10(-4) cm2 V(-1) s(-1)) when measured from the space-charge-limited current, suggesting that highly regioregular and crystalline polythiophenes are not required in order to effectively transport charges in polymer solar cells. Overall, these results suggest a design principle for semicrystalline conjugated polymers in fullerene-composite solar cells in which crystallization-driven phase separation can be dramatically suppressed via the introduction of a controlled amount of disorder into the polymer backbone.

For a recent intermediate-luminosity transient, AT 2019krl in M74 (NGC 628) at a distance of only ~9.8 Mpc, extensive archival $\textit{Hubble Space Telescope (HST)}$, $\textit{Spitzer Space Telescope}$, and Large Binocular Telescope (LBT) imaging reveal a bright optical and MIR progenitor star. A peak was detected in the infrared with an absolute magnitude of $M_{4.5\,\mu {\rm m}} = -18.4$ mag, leading us to infer a visual-wavelength peak absolute magnitude of $-$13.5 to $-$14.5. The light curve from the pre-discovery archival data indicated no outbursts over the previous 16yr. The colors, magnitudes, and inferred temperatures of the progenitor best match a 13--14 M$_{\odot}$ yellow or blue supergiant, if only foreground extinction is taken into account, or a hotter and more massive star, if any additional local extinction is included. A pre-eruption spectrum of the star reveals strong H$\alpha$ emission having a narrow line core with a width of about 200 km s$^{-1}$ (FWHM) and with wings extending to $\pm$ 2000 km s$^{-1}$. The post-eruption spectrum is fairly flat and featureless with only H$\alpha$, Na I D, [Ca II], and the Ca II near-infrared triplet in emission, with very little change in the shape of H$\alpha$ over 120 days. As in many previous intermediate-luminosity transients, AT 2019krl shows remarkable similarities to both massive luminous blue variable (LBV) eruptions and SN 2008S-like events. However, in this case, the information about the pre-eruption star allows us to clearly rule out both a super-AGB star and an electron-capture SN as the origin of this SN 2008S-like event. Instead, the data favor either a relatively unobscured blue supergiant (likely viewed pole-on) or a highly extinguished LBV with $M >$ 20 M$_{\odot}$, confirming that BSGs or LBVs that may undergo mergers are a viable progenitor pathway to produce SN 2008S-like events.

The surface contribution to the electrical transport properties of InN was directly measured and modulated by the electrolyte gated Hall effect. Undoped and Mg-doped films show different behaviors that can be effectively described by a multilayer model, taking into account the conduction contribution from both the surface and interface with the buffer layer. Gated photoluminescence experiments further show the surface accumulation layer enhances radiative electron-hole recombination in undoped InN.

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This study offers a detailed mechanistic investigation of host-guest encapsulation behavior in a new enzyme-mimetic metal-ligand host and provides the first observation of a conformational selection mechanism (as opposed to induced fit) in a supramolecular system. The Ga₄L₄ host described features a C₃-symmetric ligand motif with meta-substituted phenyl spacers, which enables the host to initially self-assemble into an S₄-symmetric structure and then subsequently isomerize to a T-symmetric tetrahedron for better accommodation of a sufficiently large guest. Selective inversion recovery ¹H NMR studies provide structural insights into the self-exchange behaviors of the host and the guest individually in this dynamic system. Kinetic analysis of the encapsulation-isomerization event revealed that increasing the concentration of guest inhibits the rate of host-guest relaxation, a key distinguishing feature of conformational selection. A comprehensive study of this simple enzyme mimic provides insight into analogous behavior in biophysics and enzymology and aims to inform the design of efficient self-assembled microenvironment catalysts.